's general knowledge of crooked fungus enteritis of jejunum

's general knowledge of crooked fungus enteritis of jejunum
Crooked fungus enteritis (campylobacter jejuni enteritis) of jejunum Bent the acute intestinal infectious disease that the fungus causes by jejunum. There are more neutral leucocytes and erythrocyte as the characteristic in clinical in order to generate heat, abdominal pain, courage and uprightness.Crooked fungus earlier than ox, sheep produced to flow automatically to isolate in the body 1909 most, call the foetus vibrios (vibrio fetus) ,It was the same as this fungus from human body's first separation in 1947. King named causing this kind of bacterium of children's enteritis by 1957 " The relevant vibrio " ( related vibrios) . Sebald and Veron found not fermented glucose of this fungus in 1973, composition and content of DNA were different from the vibrio genus, have created and used the crooked fungus (campylobacter) in order to different from the vibrio This name. The intersection of Skirrow and reform train technology by 1977, patient separate reach crooked fungus in the the excrement and urine in suffer from diarrhoea, thus has established the relation between germ and disease, and name diarrhoea caused by crooked fungus as formally crooked fungus enteritis (campylobacter enteritis) .
[Aetiology ]
Jejunum crooked the intersection of fungus and the intersection of department and one that crooked fungus belong to plant, crooked fungus belong to, divide six plant and several inferior kind into together. The crooked fungus belongs to (campylobacter genus) Including foetus' crooked fungus (campylobacter fetus) ,Crooked fungus of jejunum (c. jejuni) ,Crooked fungus of colon (c. colic) ,Crooked fungus of pylorus (c. pybridis) ,Crooked fungus of saliva (c. sputorum) And Ou's crooked fungus of sea (c. laridis) .Jejunum bend the fungus to mankind's pathogenic overwhelming majority and the foetus bends inferior kind of fungus foetus, secondly it is that a crooked fungus of large intestine is blue for leather to dye the negative a little aerobic bacillus. Long 1.5- 5 m, width 0.2- 0.5 m; Arc in shape, S shape or volution, 3- 5 are presented bunch or arranged singly; Both ends of body of fungus is sharp, there are cilias very much, can do the sports of fast straight line or spirillum; Have no membrane of pod. The excrement and urine or intestines swab sample inoculates and chooses culture medium (Skirrow ' s Butzletp ' s or Campy-BAP) ,Or inoculate on choose culture medium while being non- behind the filter through 0.65 m, in 5-10% oxygen, 3- 10% of the carbon dioxide, can separate this fungus at 42 . Can't grow in the air. The colony is very small while separating at first, about 0.5- 1mm, round, white or creamy, the surface is smooth or coarse, smooth type after transferring to kind to become a mucus type, some present refracting light of glass section kind. According to grow necessary difference of temperature, non- fermented glucose and grow in 1% glycine, 3.5% the intersection of salt and liquid, 1% culture medium of bile characteristic can distinguish their kind.The main antigen has O antigen, it is a kind of lipopolysaccharide in the afterbirth wall, and H antigen (flagellar antigen) . The intestine produce some immunity after infecting, produce IgG, IgM, IgA antibody against O in the blood too, protect strength certainly.This fungus relatively survives long in water, milk, such as the temperature survives for 3- 4 weeks at 4 ; Survive in the excrement too long, can keep vigor for nearly 96 hours in the excrement of chicken, in the person excrement if each gram includes several 108 funguses, keep vigor for nearly more than 7 dayses. The bacterium has greater endurance to the sour soda, so apt to survive through the gastrointestinal tract. Sensitive to physics and chemical disinfectant.
[Epidemiology ]
(1) It is mainly an animal to infect the source. The crooked fungus belongs to and scatters in various animal body extensively, among them carry disease germs most with the poultry, wild fowl and domestic animal. Secondly isolate the crooked fungus in the rodent too. The germ discharges outside the body through its excrement and urine, pollutes the environment. When people keep in close touch or eat the food polluted with these animals, the pathogen enters the human body. Because the animal does not mostly have carrying disease germs of symptom, and the disease-carrying rate is high, infection source and storage host that it is important.The patient can also be regarded as and infected the source, especially patients of children often because the excrement and urine is dealt with improperly, the chance is infective and big more to pollute the environment. Developing countries because the sanitary condition is bad, infect the chance more repeatedly, can form the immunity and carry disease germs. Carrier to have symptom these arrange fungus constantly, arrange the intersection of fungus and issue, as long as 6- 7 week, even 15 long in month, so infect the source. (2) Propagate a spread route that is main of excrement of route. Commercial the intersection of poultry and meat, milk, eggs of domestic animal bend into fungus, pollute more, such as take food crude or process inappropriately, eat dish cold and dressed with sauce,etc., can cause and infect. It is too very important for source of water to travel, have, report diarrhoea that crooked fungus cause 60% of patient have illness coming on, drink the history of unboiled water the last week, and only 25% of control group.In addition can also be spread to foetuses or babies vertically by the ill mother except that people spread with human world. (3) Apt perceptual people generally exchange the sense. The morbidity of children under the age of 5 of developing country is the highest, especially within a year old person. The morbidity rises and drops with age. The developing countries with better sanitary condition of developed country, the separating rate of crooked fungus of jejunum is the highest with years old age 10- 29, prove adult's immunity to this disease is no better than children. This difference between developing countries and the developed country, relate to sanitary condition, the adults of developing countries often contact and get a certain level of immunity in the body on a small quantity at ordinary times, so the morbidity is low. (4) The whole a disease of characteristic prevails to have illness coming on every year, it is many in summer. At ordinary times can distribute, can also lead to the fact, break out to prevail because of food, milk, ink pollution. Natural factor, such as the climate, rainfall; Social factor, such as quality of the sanitary condition, people's flow (travel) Can all influence the emergence of a disease and prevail.
[Onset principle and pathology change ]
The crooked fungus of jejunum causes the mechanism of the human enteritis not to totally clear yet, may have something to do with instead of attacking strength, endotoxin and ectotoxin. Two foreign wish experimenters, typical symptom appears in three days after a oral milk with fungus content of 106; Another oral food with fungus content of 500 has illness coming on on the fourth day. Jejunum crooked fungus enter digestive tract from mouth, gastric acid have on it kill function while being sure at the empty stomach, have already proved solution that pH has been less than or equal to 3.6 kills cocoa of this fungus. Gorge on or soda food do benefit to bacteria break through the stomach protective screen. Enter the enteric bacterium of to breed in the upper small intestine, and take advantage of its attacking strength and invading the skin cells on the mucous membrane. The bacterium grows and breeds and releases ectotoxin, bacterium's cleavage to produce endotoxin. Ectotoxin is similar to cholera and intestines toxin. Ectotoxin activate the intersection of adenosine and sour the intersection of ring and enzyme in the upper leather cell, and then cAMP increases, energy increases, impel mucomembranous cells to secrete vigorously, cause diarrhoea. This function can be blocked by cholera and antitoxin. Growth of germ breed and toxin lead to the fact some mucous membrane to congest, ooze out edema, ulcer, bleed even. If immunity low bacterium can spread with the blood flow, cause bacteremia, even septicaemia, and then cause the damage of brain, heart, lung, liver urine way, joint,etc..The mucomembranous pathology of intestines is checked layer P> for non- specific colitis, inherent (1) Treat digestive tract, isolate generally, stool in patient should sterilize completely, isolate issue train, turn to stool overcast having illness coming on. The persons who generate heat, suffer from abdominal pain, suffer from diarrhoea heavily for the treatment to the ill, and stay in bed. Diet give easy half liquid food that digest, appropriate fluid infusion if necessary. (2) Etiology treat fungus this to gentamicin and erythromycin, chloromycetin, Streptomycin, kanamycin, neomycin, the intersection of tetracycline and clan, forest very mould and plain and sensitive. Usually able to bear medicines to penicillin and very beginning spore's fungus. Clinic can be selected for use according to the condition. Available erythromycin of enteritis, adult 0.8- 1.2g day, children 40- 50mg/kg day, take orally, the 2nd - 3 days of course of treatment. The intersection of quinoline and the intersection of promise and ketone antimicrobial, such as Fluorine being too good in the intersection of piperazine and sour curative effect, can influence skeleton development to the infant. First-selected gentamicin of membrane inflammation in the bacterial heart. First-selected chloromycetin of meningitis. Serious disease should prolong to infect the course of treatment until 3- 4 weeks, so as not to recur.
[Prevent ]
The most important infection source of crooked disease of jejunum is an animal, how to control the infection of the animal, it is essential to prevent animal's excrement from polluting water, food. Do well, in charge of water, in charge of excrement, it in charge of foods to be to prevent crooked the intersection of fungus and effective measure that disease travel from promptly by three.Grinding at present
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