The scientist draws out the three-dimensional atlas of the human genetic high-resolution

The scientist draws out the three-dimensional atlas of the human genetic high-resolution
The scientist claims, this atlas can help to find out the pathogenic gene in the human gene
According to foreign media, through divide several million Entrance into and arrange Entrance these against preface human gene scientist, draw out the structural atlas of three-dimension of the human gene, the atlas not merely can probe into the permutation shape of the gene, still can let the scientist look for the pathogenic gene in the human gene.
The molecule biologists of the scientist medical college in Massachusetts state who draws the table picture of this high-resolution Decore (JobDekker)s Expression : " Obviously, it is the key factor that a gene is regulated that the space that the human gene hits the chromosome makes up. The show of such three-dimensional atlas, can let us explore the genetic regulation field found out in the past, can find a lot of new problems while helping us. "
Some cell biologists propose, the compression of the gene is not merely an effective memory mechanism before this, the interaction among this kind of composition way and genetic function and gene has relation. But because gene order-checking experiment will destroy shape of gene, electron microscope can't observe the compressed detailed conditions of gene even, so the research in this respect has never obtained the break-through.
In April of this year, institute's publication of American national academy of sciences has been published>,This article is offered persuasion evidence and data of the genetic shape, and draw out the low resolution ratio picture. And this publishes the high-resolution picture on the scientific magazine on October 7 at present, more exhaustive offering gene arranges the detail of the shape. Decore says : " The three-dimensional high-resolution atlas of this gene can change people's method to study the chromosome. We can link with activity of the gene through it, pursue the change of the cell structure. "
It is reported, in order to confirm the structure of the gene, the scientist soaks the nucleus in formaldehyde at first, formaldehyde can connect the gene leaning together like glue, keep the truth of the gene in three-dimensional space. Then the scientist breaks the connection between the gene by way of chemistry, only let the each other close gene be kept connecting, form the genetic chip in pairs. With the help of computer software, reinvent the connection during the gene according to original permutation order of the gene. In this way, the three-dimensional atlas of gene which draws out this high-resolution that succeeded in.
Another join the intersection of scientist and the intersection of Harvard University and angstroms of thunder, biologist of computer, that atlas draw now Lies of graceful uncle Ai Deng (ErezLieberman-Aiden) Say: " There is no node in this genetic model reinvented out, just one rolls the noodles compressed together. However, you can be under not destroying the situation of its structure, a part of arbitrary extraction among them, and can resume it the former state . "
|