Scientist find human body produce about genetic family of difference

Scientist find human body produce about genetic family of difference

The scientists have found a genetic family playing a key role at the initial period of development, at this stage, the embryo can already distinguish the inclining from side to side of the body, and begin to confirm the organ in the internal laying position. This on little mouse can make people understand better to discover how some human congenital defects took place. It is here that this research results are issued Publish on January 24 >On the network edition of the magazine .
This research is set up in breaking the development mechanism of embryo lacked about symmetrically. The research of great doctor and his colleague of Hamada, geneticist of Japan Osaka university is pointed out, lie the intersection of cell and cilium of surface of embryo in the nodal area will form left to flow outside embryo, let the embryo know which side is the left conversely. Its reason is a back department facing nodal cell of cilium, and slope to the embryo tail.
The unique position, take exercises, combine together, form left to flow clockwise with cilium, thereupon left and right sides of the embryo are symmetrical and is broken. According to study, if have setting-up that orientation flow, organism will produce the organ in the intersection of health and wrong side development, thus reduce its probability of surviving.
After understanding the important relation between cilium position and embryo development stage on the node, researchers decide to further observe one to call " L In disorder " Can if you can't lead, move until backs at cell nodal cilium. Here correctly " L In disorder " R In genetic family has studied for many years, researchers are through closing 3 respectively " L In disorder " R One in the gene come, develop little the intersection of mouse and model, with the intersection of research and his own function this. Finally, researchers find, " L In disorder " R The gene can activate the polar thorough fare of level cell, the position information that this thorough fare helps in decision cells and the tissue.
The intersection of thesis and first author, the intersection of Hamada and great the intersection of graduate student and originally and through one high-speed camera that link with microscope bridge of laboratory, ciliary movement in the little the intersection of mouse and embryo go on, monitor, observe position of the cilium changes with development process really to survive. In break, lack the intersection of development and stage initially take place, while being symmetrical while being about, cilium lie in the middle of nodal cell, with the progress of development, the cilium is transferred to the back of cells gradually.
Researchers have on cilium and tape in the little normal mouse embryo " In disorder " R The cilium in the gene mutation embryo has been compared. They find, there are cilia in gene mutation embryos that lie in the abnormal position of nodal cells, thus unable to form the left to flow.
Researchers say, this discovery is offered the information of the most basic level of human development, mankind how produce about difference on earth, this kind how difference lead to the fact heart grow in on the left also finally, and the liver grows on the right. Understanding clearly that will contribute to understanding the cause of the human congenital defect better to embryo's development process, and found the method to try to correct these defects. (Feng WeiDong ) (Source : Science and Technology Daily )
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