The scientist looks for the genetic protective screen to resist HIV to infect

The scientist looks for the genetic protective screen to resist HIV to infect
AIDS is by HIV (HIV) Cause chronic to cause the intersection of fatal character and infectious disease, begin until mankind prevailing will it be the end last century, spread in the world at the unexpected speed. According to conference of prevention and treatment of venereal diseases of the first AIDS of China held in Beijing recently, AIDS in the whole world propagates the fastest area in Asia now, from behind 1995, HIV-positive and patient of China report the straight line of the quantity rises, the spread speed is the fourth in Asia, the expert estimates the infeted may exceed 1 million people by the end of this year. A few people are not infected with AIDS by HIV good medicine and has not saved the situation yet. In the face of this serious world pestilence, the scientist in whole world uses the skill in wielding the 18 kinds of weapons, look for pathogenic clue and therapeutic medicine. And it is an important basic research among them to look for AIDS to exchange sense gene and resisting gene. The scientist has already known it has been CD4 molecule that utilized on target cells that HIV enters the human body, but curiously, change CD4 over to animal's cells, add HIV one, but animal's cells will not be infected with HIV. In addition, some crowds make the scientist puzzled too in U.S.A.: They take drug gay person, often keep in touch but not infect with the HIV-positive person. This shows, other factors play an important role in the infection of AIDS. 1996, three world-famous scientific magazines such as " Nature ", " science ", " cell " successively published the theses of relevant AIDS of many laboratories such as the state-run commune hospital of U.S.A., find CCR5 on chromosome short arm No. 3 to hasten, take receptor of the factor in gene. Take place behind the No. 185 amino acid as the intersection of CCR5 and genetic the intersection of code and area 32 bases lack, call that CCR5 32 sudden change, will produce truncated and not having wearing membrane protein of functionly on the surface of cell membrane, make addicted to macrophage HIVs (HIV- 1)Can't enter human cells, develop into AIDS. Originally, those a few people who escaped death by sheer luck, benefited from since the internal CCR5 gene lacked 32 basesed, make their organism obtain the natural protective screen of resisting HIV. This discovery considereds to be the thing that studies the milestone of the development history in AIDS. God does not especially take care of Chinese people CCR5 32 gene mutation will not produce obvious influence, if the able person, in order to reject this section of bases on the human body, make the mankind refuse AIDS except thousand li, OK? The reverie in this respect makes the whole world filled with exultation, has attracted three 0 two hospitals of infectious disease Professor Wang FuSheng, Deputy Director of research institute of PLA man too. That year, he was enduring the tumour research center of medical college of mountain to make to post-doctors in the west of New York University. With the progress of studying, the one related to AIDS is trending towards and melting the factor receptor and is being found constantly, scientist find CCR2, CCR3, SDF1 the intersection of gene and many attitude infect and have illness coming on with 1 HIV- too course have close relation. And determine to appear in American white man and European descendant, CCR5 32 grade location gene mutation rate is about 10%, it is 2%- 5% in the whole Europe, the Middle East and India. How about the state of resisting gene correlated to AIDS in Chinese crowd? Under national the intersection of natural science and the intersection of fund and subsidy, seminar of FuSheng Wang begin, exchange the intersection of sense and the intersection of gene and large attitude nature, carry on research to AIDS, crowd of Chinese, 1997. They have gathered more than 4000 blood specimen samples of 8 nationalities such as Chinese, hiding, is covered with, links in the native country of our country. The overwhelming majority is healthy crowds infected by HIV among these people, but it is high-risk group such as AIDS infection or venereal disease, homosexuality,etc. to have partly. This research is launched unusually arduously. In most early 1287 sample, they measure, get 900 find genetic location this click, have any unusual, until the end of 1998, regard as reach 970 more than example, find first CCR5 in blood specimen of Northeastener suddenly 32 grade location gene mutation, found one in people's blood specimen in Shandong shortly afterwards. They detect nearly 40 together, confirm Chinese gene mutation this 0.119% in rate so far, among them the Uygur nationality is the highest, it is 3.48%, it is secondly 1.12% to be indebted to clansmans, the Hans only find 6, sudden change rate is 0.16%, centre in the northern area to the north of Huaihe River, fail to measure to among other 5 nationalities. Through studying, they still find CCR5 32 genetic possibility is hereditary by way of Del Meng. Chinese CCR5 32 gene mutation is not only well below occidentals but also only display on a gene of the chromosome, call it, mix, shut sub sudden change, different from foreign countries chromosome whom two gene have pure to shut sub mutation. Such an individual when being attacked by HIV, too can have illness coming on, have illness coming on and the intersection of death and time may last 2- 4 or long in year. Have found the difference between a lot of Chinese group and American-European group in the research of other relevant genes such as CCR2, CCR3, SDF1 too. All results of study indicate, China has one or two people and has resisting nature on AIDS too, but most Chinese have not got especially hanging down sympathizing with of God, apter to be been infected with AIDS than occidentals. The research of wishing eagerly to find the gene therapy route has already published 18 theses at home and abroad, the previous Chinese health crowd sifts checking the work has obtained the military scientific and technological progress second prize of 2001. Professor Wang FuSheng is in the cooperation with domestic unit concerned, have also found tentatively that may have HIV- 1 different from foreign crowd to exchange some new location of the sense gene to click in the Chinese crowd, a bit new persons of some frequency of sudden change up to 485 in the intersection of Chinese and crowd. The seminar is further appraising all HIV- 1 and exchanging sense gene function and relevant mechanism while AIDS has had illness coming on at present. To infecting the relevant resisting many attitudes of gene and studying with HIV, it is easy to be perceptual to assess crowds at least to the heredity of HIV- 1; Can make the beneficial judgement to the patient's prognosis at the early stage of disease at the same time; The more important thing is that be able to assist and prevent and treat AIDS at the receptor level. To the research of Chinese crowd's genetic characteristic, will settle good foundation for developing genomic medicine of AIDS preventing and controlling in our country. Basic progress of scientific research make, cure Normal University and is encouraged clinically. Implement gene therapy and already to AIDS become a distant view goal, but Professor Wang FuSheng says, changing a gene of whole body, it's not at all that easy! The mankind needs more foundations to bind with clinic and study, our country needs more cooperation of domestic and foreign scientific research. Realizing this goal, the mankind has a section of long way Way. (offer the network in Beijing)

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