The scientist finds cells may control cells to split up to split up in the molecule passway

The scientist finds cells may control cells to split up to split up in the molecule passway
The research group that Japan speaks to OKADA, researcher of chemical research institute truth son and Boris, professor of Irish Dublin university announces, with computer to determine data go on, imitate, find the intersection of decision and the intersection of cell and split up, the intersection of cell and the intersection of hyperplasia,etc. and different inner member passway of cell of shape theoretically they. The result of study finds, the cells beginning to split up can utilize its powerful systematic structure to send out the steady signal.
Though cells have the same genetic system that parents offered, will follow their own development conditions, it is determined that it goes on different division, hyperplasia and death road. At present, the scientist has not fully understood this kind of mechanism that decides cell destiny yet. Up until now, determine the inner molecules of cell mostly rely mainly on determining his property of determining the nature, quantitative to determine that is seldom paid close attention to. The research group proliferated and split up the mechanism of the course in order to analyse and explain cells, the activity to various molecules in cells carried on quantitative analysis for a fixed period of time, and utilize computer simulation and find from the biological angle of system that controls the street map (molecule passway) of the relation among various members .
In the experiment, research group promote the intersection of cell and leather growth factor at the hyperplasia and promote the intersection of heregulin and two different growth these that cell split up through inject into MCF-7 breast cancer cell The factor, make it have different hyperplasia and division shape, then utilize amynologic method and genetic increasing degree law, carries on inner protein phosphorylation of cell and duplicating the finding amount of hereditary gene of the factor,etc. quantitatively and determines. Make computer model to analyze with the data measured from these cells, researchers have found the molecule thorough fare that only work while cells split up, and this thorough fare has adopted and controlled and studied the negative feedback that the field is being known very well, feedforward and with systematic structure such as the door.
The research group thinks, cells adopt the negative feedback and contribute to removing the noise with the systematic structure of the door, release signals steadily. The molecule passway found this time exists in the division course of cancer cell, nerve cell, immune cell too, one of the general system structure that there are cells that perhaps. This molecule passway concept makes it possible that the steady division of cells is controlled, alter the molecule passway artificially, can realize the control on cell, for example apply to the medical field of regeneration, can help cells to form steady construction. (Chen Chao )
|