The scientist finds effective metabolite preventing tumour from growing

The scientist finds effective metabolite preventing tumour from growing
News from Shanghai on April 13 account for the common malignant tumours of 40% percent of tumour in all craniums - --Neuroglia tumour, it is expected to find the new treatment. Fudan University announces today, April 10, international authoritative magazine>Have publish the article and introduced biomedical professor of research institute Xiong Yue of Fudan University, is in charge of the female good research results of the scientific research group led " The derivatized IDH1 mutation dominance of glioma inhibits enzyme from catalyzing actively, activate HIF1 " . This achievement has verified the molecule mechanism that gene mutation promotes glioma to grow tentatively, having found effective metabolite preventing tumour from growing, it is glioma and other treatments of tumours that bring the new dawn.
It is introduced, American scientist had genes that mutation took place in one to find the malignant colloid tumour last year " IDH1" . Studies have suggested, the mutation probability in continuing taking place glioma of IDH1 gene mutation reaches more than 75% percent high, probably IDH1 gene will be glioma potential making a diagnosis indicator and target.
The cell biology research office of molecule of Fudan University tackles key problems to find, IDH1 gene mutation will inhibit the vigor of IDH1 in cells, lead to the fact one kilogram of levels obviously drops in the afterbirth, but the decline of KG further causes the reducing of hydroxyl enzyme vigor proline. A series of response has caused the oxygen deficiency of cell to induce the factor (HIF1) Stability increase,last HIF signal thorough fare, be promoted tumour not to be grown finally. In this course, IDH1 gene mutation is just to step on a kick throttle in a more cost-effective manner for the growth of tumour cells, but the researchers of Fudan University are for inhibiting tumour cells from growing and finding the precious one " The brake " .
Researchers then find, a kind of internal metabolite " KG analog " R It seems that a set of systems of braking, can inhibit tumour cells from increasing effectively. This kind " KG analog " Improve metabolite in it have cell one's more own since human body,may side effects nonpoisonous and last phenomenon, extremely apt to enter cells, it is expected to be used in clinic comparatively fast.
>Allot and comment on thinking, this achievement, to announcing the gene mutation molecule mechanism of glioma has initiative meanings, " KG analog " Contain function on many other tumour growth including glioma, have developed and found a new way for the clinical tumour medicine. (The reporter reporter Luo Qian and Wang Chun )
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