The scientist finds the cancer cell measures the new law Help and look for and treat the new target to click

The scientist finds the cancer cell measures the new law Help and look for and treat the new target to click
In the cancer treatment, doctors will often circulate tumour cells (CTCs) The level is as controlling and adjusting the diagnosis basis of treatment and prognosis, but the traditional detection method is often unable to confirm CTCs level in patient's body accurately, bring the difficult problem to doctor. The American scientist discovers recently, the quality is transformed(EMT) among the upper skin Cause breast cancer patient CTCs very difficult to find into the reason to reach in the body, and measure CTCs by EMT gene expression, can offer more prognostic information to doctor, help, find new breast cancer to treat the target to order yet effectively. Discovery this treatment of cancer with research center and cancer study, release at the breast cancer seminar jointly hosted to learn in U.S.A. recently.
The intersection of research and first of thesis this author, former the intersection of university and the intersection of cancer and meters of first the intersection of May and Dr. Ge of centre, Andersen of M.D., Texas of U.S.A., point out, in among it have cover course transform quality,at take place cells leather in morphology to among fill by quality cell the transitions of the phenotypes and last ability that be moved, thus make its energy and invading improve greatly. Researchers infer, just this kind of division transfer process, make EMT-CTCs very difficult to be measured to; They still think, EMT-CTCs causes tumour cells as one kind, will cause tumour to spread directly.
Scribble and have magnetic particle of monoclonal antibody through the skin, researchers catch a few CTCs from 27 breast cancer patient's peripheral blood, utilize molecule biotechnology subsequently, such as the polymerase chain reacts, isolates RNA from it, and then find out the gene related to EMT. Researchers have already confirmed 5 EMT genes now: TWIST1, SNAIL1, SLUG, ZEB and FOXC2. They find, in 21% of the patients, at least one of these genes has situation excessively expressed, in three negative breast cancer patients of receptor, the excessive expression of EMT gene is more common. But researchers have not found EMT gene expression has been concerned with with existing between CTCs quantity.
"The present detection method has been underestimated the most important inferior group of CTCS cell, they cause tumour characteristics, have important function while tumour shifts, " Blood pathological professor Dr. James and Ruben of centre of cancer of another author who studies thesis, M.D. Andersen says. "The new detection method like us, can measure CTCs after EMT, can offer new important prognostic information, very useful as to monitoring the therapeutic effect in real time " .
Dr. Mei Ge, the state-run cancer research institute of Slovakia holds a post now. It is reported, the intersection of cancer and centre and the intersection of Slovakia and state-run the intersection of cancer and research institute, Andersen of M.D., begin, carry on proving research in breast cancer, the intersection of prostate and cancer, the intersection of cancer of colon and patient of shifting etc. already. They begin, aim at, confirm new EMT-CTCs treat whom target order, study too. (Liu HaiYing)
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