Bad reaction of alkali of the colchicum

Bad reaction of alkali of the colchicum
This product is used mainly for treating the acute outbreak of gout arthritis, prevent the acute outbreak of recuring gout arthritis. The acute gout result from an hour after taking orally of arthritis, 90% of the patients are taking medicine for 24- 48 hours the pain disappear. Absorb in the gastrointestinal tract rapidly after taking orally, the combining rate of plasma protein is low, it is only 10% one 34%. The supersession in the liver of this product, from bile and kidney (10% one 20%) Discharge. Patient excretes, increases hepatopathy from the kidney. The medicine is excreted to last about 10 days after medicines stopped. Bad reaction intensity and dosage size of this medicine have obvious relevance, to take orally is higher than the security of intravenous injection.Main bad reaction: 1. Gastrointestinal symptom Suffer from abdominal pain, suffer from diarrhoea, vomit and lose the appetite for the common early bad reaction. The incidence can reach 80%, the serious one can cause dehydration and electrolyte disorderlily etc. and behave. Long-term people can present serious bleeding gastroenteritis or suckAccept bad syndrome. 2. Muscles, the neuropathy around change Have proximal skin unable and (or) Serum creatine phosphokinase increases. Can change neuraxis dashing for ward many neuropathy around to damage at the same time in skin cells. Shown as numbness, shouting pain and unable. Skin neuropathy becomes actually rare,Long-term people and have night getting the whole to appear function slightly prevent gout. 3.Bone marrow inhibit from appear blood platelet reduce and neutral cells drop, even regenerated obstacle anaemia takes place. Can jeopardize the life sometimes. 4. Shock is shown as little urine, hematuria, smokes nipping and consciousness obstacle. The case fatality rate is high, see more the elderly. 5. Causing the lopsided literature report, 2 Down syndrome babies' father takes alkali history of colchicums for a long time because of family fever for Mediterranean. 6. Damage etc. other depilation, rash, generating heat and liver.

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